When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand (TRAIL). a closely related death ligand and investigational therapeutic. cells enter a protracted period of variable duration in which only upstream initiator caspases are active. A subsequent and sudden transition marks activation of the downstream effector caspases that rapidly dismantle the cell. https://proozya.shop/product-category/blenders/