Signaling networks that convert graded stimuli into binary. all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment. To exhaustively enumerate topologies that exhibit this switch-like behavior. we simulated all possible two- and three-component networks on random parameter sets. https://www.roneverhart.com/Mesa-Boogie-Rectifier-4x12-Cabinet-Standard-Straight-p31703/